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November 13Friday
  1. Hugging Face Blog69

    IBM releases LLMON preview models built on Granite 4.1 3B and 8B

    IBM released two experimental preview models, granite-4.1-3b-LLMON-preview and granite-4.1-8b-LLMON-preview, derived from Granite 4.1 base checkpoints and trained to consume and generate LLMON, an LLM-native markup language that marks instructions, data and requirements with reserved special-token delimiters. On the OPI benchmark the models avoid 47% more indirect prompt injection attacks than the best frontier model tested and 95% more than the best open-source model, while performing on par with Granite 4.1 Instruct on standard benchmarks. The release includes a GitHub toolkit with lossless JSON-to-LLMON converters, and the authors note the preview is for exploration, not production.

    Why it matters: IBM trained a preview model on Granite 4.1 that can read and write LLMON tags, using explicit instruction-data separation to reduce the indirect prompt injection success rate on the OPI benchmark to near zero while maintaining general capabilities.

November 12Thursday
  1. The Decoder71

    Google DeepMind releases AlphaGenome 2, shifting genomics AI from bulk tissue to single cell type resolution

    Google DeepMind has released AlphaGenome 2, a genomics model that predicts how DNA variants affect specific human cell types and finds nearly twice as many relevant gene changes as its predecessor. Trained on more than 107 million individual cell profiles from 68 tissues in humans and mice, it takes a cell's biological state as an extra input instead of predicting broadly across many tissues at once.

  2. MarkTechPost58

    Google DeepMind releases AlphaGenome 2 for cell-type-specific variant effect prediction

    Google DeepMind released AlphaGenome 2, a conditional sequence-to-function DNA model that reads a 1 Mb DNA window plus a target cell state and predicts variant effects for one cell type per call. On TenK10K single-cell eQTLs across 28 immune cell types, causal variant recall at 90% precision rose from 16% for fine-tuned AlphaGenome 1 to 30%, and direction-of-effect recall rose from 23% to 43%. The model is available through the AlphaGenome API for non-commercial research, with weights promised upon final publication and commercial use in private preview.

November 11Wednesday
  1. Google DeepMind72

    DeepMind releases AlphaGenome 2, a DNA model predicting variant effects in specific cell types

    Google DeepMind announced AlphaGenome 2, a next-generation DNA sequence model that predicts how DNA sequences and their variants affect specific human cell types. Trained on more than 107 million individual cell profiles across 68 tissues, the conditional model identified nearly twice as many expression-changing variants as the previous model, and on the TenK10K immune cell dataset it recovered 30% of causal variants versus 16% for the original AlphaGenome fine-tuned on single-cell data. It is available for non-commercial research via the AlphaGenome API and in private preview for commercial research.

    Why it matters: AlphaGenome 2 shifts from bulk-tissue averages to single-cell conditioning, roughly doubling causal variant recall on immune cell data, which matters for linking GWAS signals to specific cell types.

  2. The Verge · AI71

    Google DeepMind releases AlphaGenome 2, a genetic AI model that predicts variant effects by cell type

    Google DeepMind has unveiled AlphaGenome 2, a successor to last year's AlphaGenome that predicts how genetic variants affect individual cell types and states rather than broad tissue averages. Trained on more than 100 million individual cell profiles across 68 tissues, the model identifies nearly twice as many variants that can change gene expression as the previous state-of-the-art model, and can make predictions about new cell types and biological states without retraining. Google is offering it for non-commercial research via the AlphaGenome API from today, with a limited private preview for commercial use; DeepMind's Žiga Avsec said its finer predictions are more computationally expensive, so it will not replace AlphaGenome soon.

November 10Tuesday
  1. Amazon Science62

    Amazon releases Mitra-v2 tabular foundation model with scaled synthetic pretraining

    Amazon introduced Mitra-v2, a second-generation tabular foundation model for classification and regression, released with fine-tuned models and inference and fine-tuning code under the Apache-2.0 license on Hugging Face. It is pretrained on synthetic tables with 10 times as many rows and roughly three times as many columns as Mitra-v1, using a new hybrid SCM prior and hybrid optimizer while keeping the Transformer architecture unchanged. On TabArena, a public benchmark of 51 real-world datasets, Mitra-v2 leads the single-model field, beats Mitra-v1 on 32 of the 33 datasets both run natively, and finishes all 51 within the one-hour budget; fine-tuned Mitra-v2 also ranks first on ScoringBench.

    Why it matters: Mitra-v2 shows that widening synthetic pretraining data, rather than deepening the network, lifts a tabular foundation model to the top of TabArena's single-model field.

October 22Thursday
  1. Ai2 · Allen Institute for AI58

    Ai2 releases OlmoEarth v1.3 satellite embedding model with global precomputed embeddings and a browser explorer

    Ai2 released OlmoEarth v1.3, a satellite embedding model that turns a year of Sentinel-1, Sentinel-2 and Landsat time series into one 128-dimensional vector per 10-meter pixel, with the first 64 dimensions usable as a smaller embedding. Ai2 precomputed annual embeddings for the whole planet and published them on Source Cooperative, and its 128-dimensional embeddings scored highest on 20 of 27 evaluations against AlphaEarth Foundations and Tessera v2, including a new tropical crop benchmark called PLANTEUR. The release also includes the OlmoEarth Embeddings Explorer, a no-sign-in browser tool for comparing years, finding similar places and training small classifiers on the spot, with 2025, 2024 and 2023 global and 2017 to 2022 covering select countries; weights, pretraining data and code are open.

  2. inclusionAI Models58

    inclusionAI releases Ling-3.0-flash-Sante, a 124B healthcare-specialized MoE model

    inclusionAI released Ling-3.0-flash-Sante, a healthcare-specialized model built on Ling-3.0-flash with 124B total parameters and 5.1B active parameters per token, with weights on Hugging Face and ModelScope. It uses a hybrid-linear MoE architecture combining Kimi Delta Attention, gated MLA and sparse MoE layers, trains to 256K tokens, and enables thinking mode by default with tool calling through compatible serving frameworks. The company labels it a research model, not a medical device, and says outputs must not replace professional medical advice, diagnosis or treatment.

October 15Thursday
  1. Mistral AI71

    Mistral releases Timestral time-series foundation models, topping GIFT-Eval, TIME and fev-bench

    Mistral released Timestral, its first family of time-series foundation models, in four sizes from 5M to 209M parameters. The largest model ranks first on all three main public benchmarks, GIFT-Eval, TIME and fev-bench, among pre-trained zero-shot models from a single checkpoint without ensembling, using two-thirds of the parameters of the previous state of the art. Timestral produces probabilistic multivariate forecasts with 21 quantiles, supports past-only and known-future covariates, runs on CPU without a GPU, and is available through Mistral Forge for fine-tuning, with a GitHub repository and technical report published under a modified MIT licence.

    Why it matters: Mistral's first time-series foundation model family claims top zero-shot rankings on GIFT-Eval, TIME and fev-bench with a 209M-parameter checkpoint, offering a size-accuracy tradeoff reference for forecasting work.